Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685298 | 0.85 | L3MBTL1 (0.45) | SRD5A1L3MBTL1HSD17B10ALDH1A1MAPT | |
| SCHEMBL7689625 | 0.85 | L3MBTL1 (0.47) | SRD5A1TDP1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL6797058 | 0.85 | L3MBTL1 (0.42) | TDP1L3MBTL1 | |
| SCHEMBL7690082 | 0.85 | POLB (0.36) | SRD5A1TDP1L3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL10686153 | 0.81 | POLB (0.46) | SRD5A1TDP1L3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL7560192 | 0.75 | TP53 (0.44) | TDP1HSD17B10ALDH1A1GAAMAPT | |
| SCHEMBL16956272 | 0.69 | DRD2 (0.47) | TDP1HSD17B10ALDH1A1GRM7CYP1A2 | |
| SCHEMBL7685181 | 0.69 | ALDH1A1 (0.36) | TDP1HSD17B10ALDH1A1GAAMAPT | |
| SCHEMBL7568804 | 0.68 | TP53 (0.57) | HSD17B10ALDH1A1MAPTCYP1A2KDM4E | |
| SCHEMBL34463208 | 0.68 | MAP1LC3B (0.51) | L3MBTL1ALDH1A1GAANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |