Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 11/20 | 0.68 |
| ▸ | CNR2 | P34972 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.60 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.56 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8176472 | 0.88 | ALDH1A1 (0.55) | ICMTCNR2ALDH1A1LMNAPLA2G2A | |
| SCHEMBL2004159 | 0.85 | PLA2G2A (0.81) | ICMTCNR2ALDH1A1LMNAPLA2G2A | |
| SCHEMBL20769700 | 0.85 | LMNA (0.75) | ICMTCNR2ALDH1A1LMNAPLA2G2A | |
| SCHEMBL8166905 | 0.85 | PPARD (0.74) | ICMTCNR2ALDH1A1LMNAPLA2G2A | |
| SCHEMBL5063040 | 0.85 | ICMT (0.55) | ICMTCNR2ALDH1A1LMNAPLA2G2A | |
| SCHEMBL7679351 | 0.84 | ALDH1A1 (0.62) | ICMTALDH1A1LMNAPLA2G2APLA2G4A | |
| SCHEMBL2051630 | 0.83 | ALDH1A1 (0.80) | ALDH1A1LMNAPLA2G2A | |
| SCHEMBL8174602 | 0.82 | PPARD (0.70) | ICMTALDH1A1LMNAPLA2G2A | |
| SCHEMBL7677107 | 0.82 | ALDH1A1 (0.52) | ICMTCNR2ALDH1A1LMNAPLA2G2A | |
| SCHEMBL20769739 | 0.81 | PLA2G2A (0.83) | ICMTALDH1A1LMNAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1310706-A | Phospholipase inhibitors | GENETICS INST (US) | 2001-08-29 | — | — | CN | claimed |
| EP-1062205-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | claimed |
| WO-1999043654-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | claimed |
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |
| EP-1062205-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999043654-A2 | INHIBITORS OF PHOSPHOLIPASE ENZYMES | GENETICS INSTITUTE, INC. (US) | 1999-09-02 | — | — | WO | disclosed |