Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 3/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1824469 | 0.92 | DRD2 (0.46) | HPGDDRD2CCR2TACR2TACR1 | |
| SCHEMBL8559338 | 0.86 | TACR2 (0.55) | HPGDTACR2TACR1TACR3PROKR1 | |
| SCHEMBL5378396 | 0.85 | OPRM1 (0.52) | DRD2CCR2SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL3387438 | 0.82 | DRD2 (0.50) | DRD2CCR2TACR1MEN1KMT2A | |
| SCHEMBL3984793 | 0.81 | CCR5 (0.44) | DRD2PROKR1MEN1KMT2AOPRM1 | |
| SCHEMBL12469393 | 0.80 | PKM (0.47) | TACR2NPC1RAB9AKMT2ASLC6A3 | |
| SCHEMBL12469391 | 0.80 | PKM (0.47) | TACR2NPC1RAB9AKMT2ASLC6A3 | |
| SCHEMBL2535215 | 0.80 | CCR1 (0.46) | DRD2MEN1KMT2ASLC6A3CCR1 | |
| SCHEMBL3984899 | 0.79 | OPRM1 (0.41) | HPGDTACR2TACR1TACR3MEN1 | |
| SCHEMBL5075026 | 0.78 | DRD2 (0.44) | HPGDDRD2CCR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403612-B2 | UREA CONTAINING COMPOUNDS INHIBIT THE AGGREGATION OF BLOOD PLATELETS; NONTOXIC | MERCK & CO., INC. | 2002-06-11 | — | — | US | disclosed |
| US-20010044454-A1 | Thrombin receptor antagonists | MERCK SHARP & DOHME CORP. | 2001-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044454-A1 | Thrombin receptor antagonists | F2R, TBXA2R, PTAFR | HPGD 1210/4885DRD2 3947/4885CCR2 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.