Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685298 | 0.82 | L3MBTL1 (0.45) | TP53SRD5A1ALDH1A1MAPTPOLB | |
| SCHEMBL34463208 | 0.80 | MAP1LC3B (0.51) | ALDH1A1RAB9AHTT | |
| SCHEMBL7685135 | 0.79 | TP53 (0.46) | TP53PTGDR2PTGDRADAM17ALDH1A1 | |
| SCHEMBL14640344 | 0.70 | PTGDR2 (0.62) | PTGDR2PTGDRMAPTPOLBTSHR | |
| SCHEMBL10257352 | 0.70 | ALDH1A1 (0.44) | TP53ADAM17ALDH1A1MAPTPOLB | |
| SCHEMBL6804819 | 0.69 | TP53 (0.57) | TP53ALDH1A1MAPTPOLBTSHR | |
| SCHEMBL24252872 | 0.68 | PTGDR2 (0.46) | TP53PTGDR2PTGDRADAM17ALDH1A1 | |
| SCHEMBL1093945 | 0.68 | HTR2C (0.61) | PTGDR2PTGDRHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL1266139 | 0.67 | HTR2C (0.62) | PTGDR2PTGDRHTR3EHTR3BHTR3A | |
| SCHEMBL7680981 | 0.67 | ALDH1A1 (0.33) | ALDH1A1MAPTPOLBKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |