Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 10/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.60 |
| ▸ | FLT3 | P36888 | 4/20 | 0.60 |
| ▸ | CCR2 | P41597 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6865628 | 0.92 | PDGFRB (0.60) | PDGFRBPDGFRAFLT3CCR2MEN1 | |
| SCHEMBL6866879 | 0.89 | PDGFRB (0.63) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL6867612 | 0.85 | CCR2 (0.61) | CCR2KMT2AKDM4EMAPT | |
| SCHEMBL6864433 | 0.83 | PDGFRB (0.67) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL9536869 | 0.81 | CCR2 (0.76) | CCR2KDM4EMAPT | |
| SCHEMBL6867577 | 0.80 | FLT3 (0.63) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL9622481 | 0.76 | NOD2 (0.64) | CCR2MEN1KMT2ATSHRKDM4E | |
| SCHEMBL6865103 | 0.76 | FLT3 (1.00) | PDGFRBPDGFRAFLT3MEN1KMT2A | |
| SCHEMBL9622982 | 0.76 | CCR2 (0.58) | CCR2KMT2AKDM4EMAPT | |
| SCHEMBL3956751 | 0.74 | CCR2 (0.84) | CCR2KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407102-B1 | TYROSINE KINASE AND PLATELET-DERIVED GROWTH FACTOR INHIBITORS; ANTICARCINOGENIC, ANTITUMOR, ANTIARTHRITIC AND ANTIPROLIFERATIVE AGENTS; RESTENOSIS, ARTERIOSCLEROSIS | ZENTARIS AG (DE) | 2002-06-18 | — | — | US | disclosed |