Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.35 |
| ▸ | GCGR | P47871 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MATK | P42679 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624151 | 0.86 | HAO1 (0.39) | MAPK14GCGRGSK3BMAPK13PRKD3 | |
| SCHEMBL7542111 | 0.84 | PTGS2 (0.44) | — | |
| SCHEMBL6623410 | 0.83 | CHRNA7 (0.43) | ALOX5CDK2 | |
| SCHEMBL7538974 | 0.80 | HAO2 (0.43) | ALDH1A1ARHTT | |
| SCHEMBL7671604 | 0.77 | ALDH1A1 (0.35) | MAPK14GCGRMAPK13MAPK12MAPK11 | |
| SCHEMBL6620206 | 0.74 | PTGS2 (0.44) | — | |
| SCHEMBL6440359 | 0.74 | ALDH1A1 (0.41) | MAPK14GCGRGSK3BMAPK13PRKD3 | |
| SCHEMBL6622736 | 0.73 | MAPK14 (0.44) | MAPK14GCGRGSK3BMAPK13PRKD3 | |
| SCHEMBL6623323 | 0.73 | MAPK14 (0.44) | MAPK14GCGRGSK3BMAPK13PRKD3 | |
| SCHEMBL8639382 | 0.71 | MAPK14 (0.44) | MAPK14GCGRGSK3BMAPK13PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6472416-B1 | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors | ABBOTT LABORATORIES | 2002-10-29 | — | — | US | disclosed |