Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.36 |
| ▸ | GCGR | P47871 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685448 | 0.86 | MAPK14 (0.35) | ALDH1A1MAPK14GCGRMAPK13PRKD3 | |
| SCHEMBL6619195 | 0.83 | PTGS2 (0.45) | — | |
| SCHEMBL6440359 | 0.74 | ALDH1A1 (0.41) | MAPK1KDM4EALDH1A1LMNANPC1 | |
| SCHEMBL6623323 | 0.74 | MAPK14 (0.44) | MAPK14GCGRMAPK13PRKD3MAP4K4 | |
| SCHEMBL6622736 | 0.74 | MAPK14 (0.44) | MAPK14GCGRMAPK13PRKD3MAP4K4 | |
| SCHEMBL8639382 | 0.72 | MAPK14 (0.44) | MAPK14GCGRMAPK13PRKD3MAP4K4 | |
| SCHEMBL6622652 | 0.70 | PTGS2 (0.41) | HPGDPOLB | |
| SCHEMBL7542111 | 0.70 | PTGS2 (0.44) | — | |
| SCHEMBL6623410 | 0.69 | CHRNA7 (0.43) | ALOX5CDK2 | |
| SCHEMBL3973566 | 0.69 | PKM (0.41) | HAO1MAPK1PKMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206474-B1 | SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS | ABBOTT LAB (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6472416-B1 | Sulfonylphenylpyrazole compounds useful as COX-2 inhibitors | ABBOTT LABORATORIES | 2002-10-29 | — | — | US | disclosed |