SCHEMBL7687307

SCHEMBL7687307

CCOC(=O)C1=C(C)NC(c2ccccc2)=C(C(=O)OCC)C1C(OC)OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 15/20 1.00
TRPV1 Q8NER1 3/20 0.60
TMIGD3 P0DMS9 2/20 0.58
ALDH1A1 P00352 2/20 0.53
CACNA1D Q01668 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7680777 0.82 ADORA3 (1.00) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL7687629 0.81 ADORA3 (0.75) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL1664685 0.78 ADORA3 (0.71) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL7685108 0.77 ADORA3 (0.74) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL7685244 0.76 ADORA3 (0.67) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL7689462 0.75 ADORA3 (1.00) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL6962273 0.74 ADORA3 (0.58) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D
SCHEMBL11232571 0.73 ADORA3 (0.57) ADORA3ALDH1A1CACNA1D
SCHEMBL13932305 0.73 ADORA3 (1.00) ADORA3TRPV1TMIGD3ALDH1A1
SCHEMBL8327248 0.72 ADORA3 (0.68) ADORA3TRPV1TMIGD3ALDH1A1CACNA1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US claimed
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US disclosed