SCHEMBL768820

SCHEMBL768820

COC(=O)CCc1cc(-n2nc3ccc(C(F)(F)F)cc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.41
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.37
MAOB P27338 3/20 0.37
MAOA P21397 2/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
AGTR1 P30556 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
ACHE P22303 1/20 0.35
VCAM1 P19320 1/20 0.35
IDH1 O75874 2/20 0.34
PTGS1 P23219 1/20 0.34
MCHR1 Q99705 1/20 0.34
S1PR1 P21453 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29353898 1.00 GAA (0.41) GAAKMT2AMEN1MAOBMAOA
SCHEMBL13546033 0.90 KDM4E (0.35) GAAKMT2AMEN1MAOBMAOA
SCHEMBL7523053 0.90 KDM4E (0.35) GAAKMT2AMEN1MAOBMAOA
SCHEMBL2641087 0.89 GAA (0.38) GAAKMT2AMEN1MAOBMAOA
SCHEMBL13715026 0.89 GAA (0.38) GAAKMT2AMEN1MAOBMAOA
SCHEMBL3287360 0.89 LIPC (0.34) GAAKMT2AMEN1MAOBMAOA
SCHEMBL3287824 0.89 LIPC (0.34) GAAKMT2AMEN1MAOBMAOA
SCHEMBL6287742 0.88 GAA (0.42) GAAKMT2AMEN1MAOBMAOA
SCHEMBL6864261 0.88 RPS6KA3 (0.35) GAAKMT2AMEN1MAOBMAOA
SCHEMBL3290027 0.87 GAA (0.35) GAAKMT2AMAOBALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 697 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391949-B1 None US claimed
JP-4705249-B2 2011-06-22 JP claimed
EP-1175467-B1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM CIBA SC HOLDING AG (CH) 2006-06-14 EP claimed
US-20050171253-A1 Containers or films comprising hydroxyphenlbenzotriazole uv absorbers for protecting contents against the effects of uv radiation CIBA SPECIALTY CHEMICALS CORP. 2005-08-04 US claimed
JP-2005517787-A 2005-06-16 JP claimed
US-20050123691-A1 Photo-cured and stabilized coatings SUHADOLNIK JOSEPH (US) 2005-06-09 US claimed
EP-1476503-A1 CONTAINERS OR FILMS COMPRISING HYDROXYPHENYLBENZOTRIAZOLE UV ABSORBERS FOR PROTECTING CONTENTS AGAINST THE EFFECTS OF UV RADIATION Ciba SC Holding AG (CH) 2004-11-17 EP claimed
US-6800676-B2 ULTRAVIOLET RADIATION ABSORBERS; HEAT AND OXIDATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2004-10-05 US claimed
US-20040191447-A1 storage of food, beverages, drugs or cosmetics in radiation transparent plastic containers having coatings comprising stabilizer agents selected from hydroxyphenyl benzotriazole ultraviolet radiation absorber materials ANDREWS STEPHEN M (US) 2004-09-30 US claimed
US-6797751-B2 A CLEAR OR LIGHTLY COLORED PLASTIC CONTAINERS OR FILMS COMPRISING A BENZOTRIAZOLES OR TRIS-ARYL-S-TRIAZINES STABILIZER; PROTECTIVE DEVICES FOR FOODS, BEVERAGES, DRUGS, COSMETICS, SHAMPOO CIBA SPECIALTY CHEMICALS CORPORATION 2004-09-28 US claimed
EP-1175467-A1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM Ciba SC Holding AG (CH) 2002-01-30 EP claimed
US-20010034449-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-10-25 US claimed
US-20010031872-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-10-18 US claimed
US-6296674-B1 Candle wax stabilized with red-shift benzotriazoles CIBA SPECIALTY CHEMICALS CORPORATION 2001-10-02 US claimed
US-20010018520-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith GALBO JAMES P (US) 2001-08-30 US claimed
WO-2001057125-A1 CANDLE WAX STABILIZED WITH RED-SHIFTED BENZOTRIAZOLES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2001-08-09 WO claimed
US-6268415-B1 POLYMERS AND STABILIZERS FOR ENHANCED STABILITY CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-31 US claimed
US-6262151-B1 FOR AUTOMOTIVE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-17 US claimed
US-6187845-B1 LAMINATION OR MULTILAYER STRUCTURE CIBA SPECIALTY CHEMICALS CORPORATION 2001-02-13 US claimed
WO-2000066676-A1 STABILIZED ADHESIVE COMPOSITIONS CONTAINING HIGHLY SOLUBLE, RED-SHIFTED, PHOTOSTABLE BENZOTRIAZOLE UV ABSORBERS AND LAMINATED ARTICLES DERIVED THEREFROM CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-11-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010034449-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 GAA 1582/4885KMT2A 617/4885MEN1 2812/4885
US-20010018520-A1 Hydroxy-substituted N-alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 GAA 1582/4885KMT2A 617/4885MEN1 2812/4885
US-20010031872-A1 Hydroxy-substituted N-Alkoxy hindered amines and compositions stabilized therewith POLH, OGG1, OGFOD1 GAA 1582/4885KMT2A 617/4885MEN1 2812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.