Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.66 |
| ▸ | HTR1D | P28221 | 1/20 | 0.66 |
| ▸ | HTR1B | P28222 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | HTR7 | P34969 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.66 |
| ▸ | HTR2B | P41595 | 1/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681514 | 0.93 | — | — | |
| SCHEMBL8101997 | 0.86 | DRD4 (0.65) | HTR1AADRA2AADRA2BADRA2CDRD4 | |
| SCHEMBL7681457 | 0.82 | HTR1A (0.60) | HTR1AADRA2AADRA2BADRA2CDRD4 | |
| SCHEMBL7681588 | 0.80 | HTR1A (0.58) | HTR1AHTR2AHTR7 | |
| SCHEMBL8103431 | 0.80 | DRD2 (0.60) | HTR1AADRA2AADRA2BADRA2CDRD4 | |
| SCHEMBL8103432 | 0.79 | HTR1A (0.64) | HTR1AADRA2AADRA2BADRA2CDRD4 | |
| SCHEMBL4546508 | 0.79 | HTR1A (1.00) | HTR1AADRA2AADRA2BADRA2CDRD4 | |
| SCHEMBL8558678 | 0.79 | HTR1A (1.00) | HTR1AADRA2AADRA2BADRA2CDRD4 | |
| SCHEMBL6526368 | 0.79 | DRD2 (0.85) | HTR1AADRA1DHTR2AHTR7ADRA1A | |
| SCHEMBL14761349 | 0.79 | HTR1A (0.79) | HTR1AADRA2AADRA2BADRA2CDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413966-B1 | SEROTONERGIC AND CENTRAL DOPAMINERGIC ACTIVITY; AFFINITY FOR 5HT1A AND 5HT2 SEROTONIN AND D2 DOPAMINE RECEPTORS; ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIA | FAES, FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS, S.A. | 2002-07-02 | — | — | US | claimed |
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |