Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.64 |
| ▸ | DRD4 | P21917 | 6/20 | 0.62 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | HRH2 | P25021 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101997 | 0.87 | DRD4 (0.65) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| SCHEMBL7690136 | 0.79 | HTR1A (0.66) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| SCHEMBL8103814 | 0.79 | HTR1A (0.63) | HTR1AADRA1DADRA1ADRD4DRD2 | |
| SCHEMBL8108057 | 0.77 | HTR1A (0.61) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| SCHEMBL8109562 | 0.76 | DRD2 (0.58) | HTR1AADRA1ADRD2DRD3HTR7 | |
| SCHEMBL7838368 | 0.76 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| Hydrochloric Acid SCHEMBL8043712 | 0.75 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| SCHEMBL8558678 | 0.74 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| SCHEMBL4546508 | 0.74 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BDRD4 | |
| SCHEMBL6526368 | 0.74 | DRD2 (0.85) | HTR1AADRA1DADRA1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057820-A1 | Arylpiperazinylalkyl-3(2H)-pyridazinones as serotonin 5HT and dopamine D2 receptor agonists | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-12-06 | — | — | EP | claimed |