Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.50 |
| ▸ | CYBB | P04839 | 1/20 | 0.50 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | CTSS | P25774 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690724 | 0.80 | MAPT (0.58) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL7002208 | 0.73 | NOX1 (0.54) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL4259575 | 0.71 | CTSK (0.36) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL23059883 | 0.69 | NOX1 (0.69) | NOX1CYBBNOX3NOX4MAPT | |
| Phenothiazine SCHEMBL6532335 | 0.68 | NOX1 (1.00) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL29475150 | 0.68 | NOX1 (1.00) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL560225 | 0.68 | NOX1 (1.00) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL6999835 | 0.67 | NOX1 (0.56) | NOX1CYBBNOX3NOX4MAPT | |
| Benzene SCHEMBL29242186 | 0.66 | NOX1 (0.97) | NOX1CYBBNOX3NOX4MAPT | |
| SCHEMBL10193005 | 0.66 | MAPT (0.65) | NOX1CYBBNOX3NOX4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002539202-A | — | — | 2002-11-19 | — | — | JP | claimed |
| EP-1163233-A1 | FUSED 1,4-THIAZINE-2-CARBONITRILE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2001-12-19 | — | — | EP | claimed |
| WO-2000055147-A1 | FUSED 1,4-THIAZINE-2-CARBONITRILE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-09-21 | — | — | WO | claimed |