Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL768512 | 0.78 | PARP10 (0.54) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL769021 | 0.76 | ACVRL1 (0.40) | CYP11B1CYP11B2CYP1A2CCNB2CDK1 | |
| SCHEMBL760693 | 0.76 | CCNB2 (0.37) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL768667 | 0.72 | CYP11B1 (0.36) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL25828286 | 0.69 | PKM (0.40) | CCNB2CDK1CCNB1GSK3BCCNB3 | |
| SCHEMBL750802 | 0.68 | CYP2A6 (0.42) | CYP11B1CYP11B2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL768861 | 0.68 | CYP11B1 (0.50) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL768995 | 0.67 | CYP11B1 (0.35) | CYP11B1CYP11B2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL751165 | 0.67 | CYP11B2 (0.49) | CYP11B1CYP11B2CYP19A1CYP17A1CYP1A2 | |
| SCHEMBL29778811 | 0.67 | PKM (0.38) | CCNB2CDK1CCNB1GSK3BCCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778972-B2 | 5-pyridin-3-yl-1, 3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1 | NOVARTIS AG (CH) | 2014-07-15 | — | — | US | disclosed |
| US-20120071512-A1 | 5-PYRIDIN-3-YL-1, 3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | NOVARTIS AG (CH) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071512-A1 | 5-PYRIDIN-3-YL-1, 3-DIHYDRO-INDOL-2-ON DERIVATIVES AND THEIR USE AS MODULATORS OF ALDOSTERONE SYNTHASE AND/OR CYP11B1 | CYP11B1, HSD11B1, CYP11B2 | CYP11B1 1/4885CYP11B2 3/4885CYP19A1 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.