Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 7/20 | 0.43 |
| ▸ | RARA | P10276 | 6/20 | 0.38 |
| ▸ | RARB | P10826 | 6/20 | 0.38 |
| ▸ | RARG | P13631 | 6/20 | 0.38 |
| ▸ | TPMT | P51580 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074818 | 0.83 | ALDH1A1 (0.38) | HIF1AMAPT | |
| SCHEMBL18042395 | 0.81 | FPR2 (0.34) | CNR1MAPT | |
| SCHEMBL20031232 | 0.81 | RARA (0.38) | TTRRARARARBRARGTPMT | |
| SCHEMBL25114081 | 0.81 | TTR (0.43) | TTRTPMTTSHRALBMAOA | |
| SCHEMBL16615463 | 0.80 | KMO (0.50) | — | |
| SCHEMBL26579752 | 0.78 | CA12 (0.49) | TTRTPMTTSHRGPR35 | |
| SCHEMBL22672668 | 0.77 | PTGES (0.40) | TTRRARARARBRARGTPMT | |
| SCHEMBL18042356 | 0.77 | — | — | |
| SCHEMBL22672586 | 0.76 | MAPT (0.38) | RARBRARGTPMTTSHRGPR35 | |
| SCHEMBL26579791 | 0.76 | TTR (0.39) | TTRTPMTTSHRALBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500405-B1 | EVALUATING THE SENSITIVITY OF A TEST CELL POPULATION TO AN ANTITUBULIN COMPOUND COMPRISING INCUBATING CELLS OR CELL EXTRACTS WITH AN AMIDE PROBE IN THE PRESENCE AND ABSENCE OF AN ANTITUBULIN TEST COMPOUND | DOW AGROSCIENCES LLC | 2002-12-31 | — | — | US | disclosed |
| US-6140362-A | INHIBITING MAMMALIAN CELL GROWTH IN BENIGN OR MALIGNANT TUMORS COMPRISING TREATING SAID CELLS WITH AN EFFECTIVE AMOUNT OF A N-ACETONYLARYLAMIDES COMPOUND | ROHM AND HAAS COMPANY (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0843018-B1 | Use of certain amides as probes for detection of antitubulin activity and resistance monitoring | ROHM & HAAS (US) | 2000-07-05 | — | — | EP | disclosed |
| EP-0843018-A1 | Use of certain amides as probes for detection of antitubulin activity and resistance monitoring | ROHM AND HAAS COMPANY (US) | 1998-05-20 | — | — | EP | disclosed |
| EP-0834311-A1 | Method for inhibiting the growth of mammalian cells | ROHM AND HAAS COMPANY (US) | 1998-04-08 | — | — | EP | disclosed |