Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.42 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.42 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5582592 | 0.79 | ROCK2 (0.56) | ROCK2TSHRTRPV1ALDH1A1HTT | |
| SCHEMBL5582721 | 0.75 | RAB9A (0.55) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL5582928 | 0.73 | CACNA2D1 (0.46) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL5582638 | 0.72 | CYP3A4 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5582758 | 0.72 | USP2 (0.42) | ROCK2ROCK1TSHRTRPV1ALDH1A1 | |
| SCHEMBL5582749 | 0.68 | ACHE (0.41) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL18983568 | 0.65 | SMN1; SMN2 (0.56) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4526386 | 0.65 | FPR2 (0.67) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6410493 | 0.65 | MMP1 (0.57) | PSMB8PSMB5PSMB10PSMB2PSMB9 | |
| SCHEMBL6248582 | 0.64 | TACR2 (0.65) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218336-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021577-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-03-29 | — | — | WO | disclosed |