Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27767907 | 0.79 | MAOA (0.40) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL28015460 | 0.76 | MAOA (0.44) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL7532162 | 0.76 | ALDH1A1 (0.41) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL8347115 | 0.75 | MAOA (0.54) | DPP4MAOAMAOBOPRM1OPRL1 | |
| SCHEMBL156160 | 0.75 | MAOA (0.54) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL28001928 | 0.74 | MAOA (0.39) | DPP4MAOAMAOBOPRM1OPRL1 | |
| SCHEMBL28001926 | 0.74 | MAOA (0.39) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL1588016 | 0.73 | MAOA (0.52) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL4581280 | 0.73 | MAOA (0.52) | MAOAMAOBOPRM1OPRL1GAA | |
| SCHEMBL268688 | 0.73 | MAOA (0.52) | MAOAMAOBOPRM1OPRL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387893-B1 | ADRENERGIC BLOCKING AGENT; BENIGN PROSATATIC HYPERPLASIA | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |
| US-6326372-B1 | BENIGN PROSTATE HYPERPLASIA | MERCK & CO., INC. | 2001-12-04 | — | — | US | disclosed |