Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12326844 | 0.89 | ALDH1A1 (0.50) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL13304834 | 0.87 | ALDH1A1 (0.61) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL26426539 | 0.87 | HTT (0.50) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL15983820 | 0.86 | ALDH1A1 (0.55) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL20973734 | 0.86 | ALDH1A1 (0.48) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL30148598 | 0.86 | ALDH1A1 (0.48) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL31148683 | 0.82 | ERN1 (0.47) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL31148800 | 0.82 | ALDH1A1 (0.44) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL27455048 | 0.82 | ALDH1A1 (0.46) | TSHRALDH1A1TDP1GPR35CYP3A4 | |
| SCHEMBL24723042 | 0.81 | ALDH1A1 (0.47) | TSHRALDH1A1TDP1GPR35CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122036699-A | THR-beta modulators and methods of use thereof | 阿利戈斯治疗公司 | 2026-05-15 | — | — | CN | disclosed |
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | ALIGOS THERAPEUTICS, INC. (US) | 2025-10-02 | — | — | US | disclosed |
| US-12338206-B2 | Compounds and their uses as thyroid hormone receptor agonists | NANJING RUIJIE PHARMA CO., LTD. (CN) | 2025-06-24 | — | — | US | disclosed |
| US-20250109132-A1 | COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | DESIGN THERAPEUTICS INC (US) | 2025-04-03 | — | — | US | disclosed |
| EP-4523692-A2 | MODULATORS OF THR-SS AND METHODS OF USE THEREOF | Aligos Therapeutics, Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| CN-119431265-A | Compound as thyroid hormone receptor agonist | 南京瑞捷医药科技有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-114621207-B | Compound serving as thyroid hormone beta receptor agonist and application thereof | 广东东阳光药业股份有限公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-114195764-B | Compound serving as thyroid hormone beta receptor agonist and application thereof | 广东东阳光药业股份有限公司 | 2025-01-17 | — | — | CN | disclosed |
| WO-2025014200-A1 | COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 티움바이오 | 2025-01-16 | — | — | WO | disclosed |
| EP-3965884-B1 | MODULATORS OF THR-BETA WITH A DIOXO-1,2,4-TRIAZYL HEAD GROUP | ALIGOS THERAPEUTICS INC (US) | 2025-01-15 | — | — | EP | disclosed |
| US-20020193610-A1 | Indazoles | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-19 | — | — | US | disclosed |
| WO-2001047919-A9 | SUBSTITUTED OXAZOLIDINONES AND THEIR USE IN THE FIELD OF BLOOD COAGULATION | BAYER AG (DE) | 2002-12-19 | — | — | WO | disclosed |
| WO-2002090344-A1 | AMIDO-DIPHENYL DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-11-14 | — | — | WO | disclosed |
| WO-2002051805-A1 | INDOLE DERIVATIVES AS LIGANDS OF THYROID RECEPTORS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |
| WO-2002022586-A1 | INDAZOLES HAVING AN ACTION SIMILAR TO THAT OF A THYROID HORMONE, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE IN MEDICAMENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-03-21 | — | — | WO | disclosed |
| WO-2002012169-A1 | AMINO DIPHENYL ETHERS AND AMIDO DIPHENYL ETHERS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-02-14 | — | — | WO | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |
| EP-0488756-B1 | Oxidizable color producing reagent | WAKO PURE CHEM IND LTD (JP) | 1997-02-26 | — | — | EP | disclosed |
| US-5238818-A | Derivative of p-fluoroaniline with 4-aminoantipyrine | WAKO PURE CHEMICALS CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0488756-A1 | Oxidizable color producing reagent | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1992-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250304561-A1 | MODULATORS OF THR-BETA AND METHODS OF USE THEREOF | THRB, THRA, TRHR | TSHR 4/4885ALDH1A1 3330/4885TDP1 581/4885 |
| US-12338206-B2 | Compounds and their uses as thyroid hormone receptor agonists | THRA, THRB, TSHR | TSHR 3/4885ALDH1A1 2039/4885TDP1 1640/4885 |
| US-20020193610-A1 | Indazoles | CYP3A43, CYP3A5, CYP3A4 | TSHR 3101/4885ALDH1A1 698/4885TDP1 2480/4885 |
| US-20250109132-A1 | COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN2, ATXN2L, ATXN10 | TSHR 2574/4885ALDH1A1 4371/4885TDP1 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.