Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.52 |
| ▸ | DHFR | P00374 | 3/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694814 | 0.80 | DHFR (0.67) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7691835 | 0.79 | ALDH1A1 (0.54) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7696922 | 0.78 | ALDH1A1 (0.56) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL14747429 | 0.73 | CACNA1C (0.66) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7690975 | 0.73 | ALDH1A1 (0.64) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7695444 | 0.73 | ALDH1A1 (1.00) | ALDH1A1ALOX12ADORA2BLMNAMAPT | |
| SCHEMBL7693299 | 0.72 | SMN1; SMN2 (0.60) | ALDH1A1ALOX12DHFRADORA2BCA1 | |
| SCHEMBL7693397 | 0.72 | MAPT (0.64) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7695612 | 0.70 | ALDH1A1 (0.56) | ALDH1A1ALOX12CACNA1FCACNA1DCACNA1S | |
| SCHEMBL7690939 | 0.70 | CA1 (0.65) | ALDH1A1ALOX12DHFRADORA2BCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066443-A2 | 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |