Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.32 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705891 | 0.89 | ALDH1A1 (0.38) | NOS3NOS2ALDH1A1KDM4EMAOA | |
| SCHEMBL7703215 | 0.80 | KMT2A (0.44) | NOS3NOS2ALDH1A1KDM4EMAOA | |
| SCHEMBL7702368 | 0.77 | NOS3 (0.41) | NOS3NOS2ALDH1A1KDM4EMAOA | |
| SCHEMBL7698346 | 0.76 | TSHR (0.42) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL5213961 | 0.71 | ALDH1A1 (0.55) | NOS3NOS2ALDH1A1KDM4EMAOA | |
| Hydrochloric Acid SCHEMBL8331052 | 0.70 | ALDH1A1 (0.54) | NOS3NOS2ALDH1A1KDM4EMAOA | |
| SCHEMBL8510510 | 0.67 | NOS3 (0.41) | NOS3NOS2ALDH1A1KDM4EMAOA | |
| SCHEMBL28842917 | 0.66 | PARP1 (0.43) | KDM4EPLA2G10BCAT2 | |
| SCHEMBL7702576 | 0.66 | PRCP (0.43) | MAPTNPSR1MEN1KMT2A | |
| SCHEMBL7706815 | 0.65 | BCAT2 (0.47) | NOS3NOS2ALDH1A1KDM4EMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |