Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.44 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.44 |
| ▸ | RUVBL1 | Q9Y265 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698685 | 0.93 | DGAT1 (0.50) | DGAT1TMPRSS4RUVBL1HSP90AA1HSP90AB1 | |
| SCHEMBL7695533 | 0.88 | ADCY8 (0.47) | DGAT1TMPRSS4RUVBL1HSP90AA1HSP90AB1 | |
| SCHEMBL7701479 | 0.85 | HSP90AA1 (0.54) | DGAT1HSP90AA1HSP90AB1PDK1MAPT | |
| SCHEMBL7699293 | 0.82 | KDM4E (0.53) | DGAT1TMPRSS4RUVBL1ADCY8ADCY1 | |
| SCHEMBL7699604 | 0.82 | MAPT (0.47) | DGAT1HSP90AA1HSP90AB1PDK1MAPT | |
| SCHEMBL7695132 | 0.81 | MAPT (0.49) | DGAT1HSP90AA1HSP90AB1PDK1MAPT | |
| SCHEMBL7699719 | 0.80 | MAPT (0.46) | MAPTKDM4EHTT | |
| SCHEMBL7701239 | 0.80 | MAPT (0.60) | HSP90AA1HSP90AB1PDK1MAPTKDM4E | |
| SCHEMBL7694290 | 0.80 | TACR1 (0.51) | — | |
| SCHEMBL7695765 | 0.79 | ALDH1A1 (0.50) | THRBMAPTKDM4EPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002064558-A2 | OXAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS CYTOKINE INHIBITORS | SANKYO COMPANY, LIMITED (JP) | 2002-08-22 | — | — | WO | disclosed |