SCHEMBL770144

SCHEMBL770144

O=C(O)Cn1cc(I)c(=O)[nH]c1=O

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.60
GRIA1 P42261 4/20 0.60
GRIA2 P42262 4/20 0.60
GRIA4 P48058 4/20 0.60
GRIK5 Q16478 4/20 0.60
CYP1A2 P05177 2/20 0.60
BLM P54132 1/20 0.60
HSD17B10 Q99714 1/20 0.60
TYMP P19971 1/20 0.41
LMNA P02545 1/20 0.40
KDM4E B2RXH2 2/20 0.39
GRIA3 P42263 1/20 0.39
MAPT P10636 2/20 0.39
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
TK1 P04183 2/20 0.38
CYP2C9 P11712 1/20 0.38
PYGM P11217 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20088133 0.83 CYP1A2 (0.57) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL7718378 0.81 KMT2A (0.52) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL31282172 0.79 KMT2A (0.49) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL30423828 0.79 GRIA1 (0.60) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL692624 0.79 LMNA (0.61) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL456749 0.79 HPGD (0.57) TYMPTK1
SCHEMBL2153060 0.79 GRIA1 (0.60) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL17123686 0.78 KMT2A (0.49) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL31281981 0.77 KMT2A (0.44) KMT2AGRIA1GRIA2GRIA4GRIK5
SCHEMBL136440 0.76 HDAC6 (0.43) KMT2AGRIA1GRIA2GRIA4GRIK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4182736-A1 OPTICALLY ACTIVE DEVICES AMO Ireland (IE) 2023-05-24 EP disclosed
US-20190317040-A1 DEVICES AND METHODS FOR TARGET MOLECULE CHARACTERIZATION ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-17 US disclosed
US-10442771-B2 Trans-base tunnel reader for sequencing ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-10-15 US disclosed
US-10330632-B2 Devices and methods for target molecule characterization ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-06-25 US disclosed
US-20170204066-A1 NANOPORE BASED SEQUENCER ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2017-07-20 US disclosed
US-9593372-B2 Nanopore based sequencer ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2017-03-14 US disclosed
US-20160319334-A1 DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING THE LIGASE DETECTION REACTION WITH ADDRESSABLE ARRAYS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-11-03 US disclosed
US-9395352-B2 Devices and methods for target molecule characterization ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2016-07-19 US disclosed
US-9234241-B2 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays CORNELL RESEARCH FOUNDATION, INC. (US) 2016-01-12 US disclosed
US-9206477-B2 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays CORNELL RESEARCH FOUNDATION, INC. (US) 2015-12-08 US disclosed
US-20100084276-A1 Devices and Methods for Target Molecule Characterization NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-04-08 US disclosed
WO-2009117517-A2 NANOPORE AND CARBON NANOTUBE BASED DNA SEQUENCER ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2009-09-24 WO disclosed
US-7384749-B2 Electrodes linked via conductive oligomers to nucleic acids CLINICAL MICRO SENSORS, INC. (US) 2008-06-10 US disclosed
US-20060211016-A1 Electrodes linked via conductive oligomers to nucleic acids CLINICAL MICRO SENSORS, INC. 2006-09-21 US disclosed
US-7056669-B2 AC methods for the detection of nucleic acids CLINICAL MICRO SENSORS, INC. (US) 2006-06-06 US disclosed
US-7045285-B1 Electronic transfer moieties attached to peptide nucleic acids CLINICAL MICRO SENSORS, INC. (US) 2006-05-16 US disclosed
US-20030148328-A1 AC methods for the detection of nucleic acids ROCHE MOLECULAR SYSTEMS, INC. 2003-08-07 US disclosed
US-6495323-B1 NUCLEIC ACIDS COVALENTLY COUPLED TO ELECTRODES VIA CONDUCTIVE OLIGOMERS CLINICAL MICRO SENSORS, INC. 2002-12-17 US disclosed
US-6232062-B1 HYBRIDIZATION CLINICAL MICRO SENSORS, INC. 2001-05-15 US disclosed
US-6090933-A ATTACHING THE SULFUR OF A CONDUCTIVE OLIGOMER HAVING A FIRST SUBUNIT OF A SULFUR ATOM PROTECTED BY ETHYL PYRIDINE OR TRIMETHYLSILYL ETHYL, TO THE GOLD ELECTRODE; NUCLEIC ACIDS COVALENTLY COUPLED TO ELECTRODES VIA CONDUCTIVE OLIGOMERS CLINICAL MICRO SENSORS, INC. (US) 2000-07-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170204066-A1 NANOPORE BASED SEQUENCER DNMT3A, DNTT, TELO2 KMT2A 2083/4885GRIA1 4598/4885GRIA2 4167/4885
US-10442771-B2 Trans-base tunnel reader for sequencing DNTT, TRDMT1, TELO2 KMT2A 2184/4885GRIA1 4069/4885GRIA2 3743/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.