Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.40 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707357 | 1.00 | OPRM1 (0.40) | OPRM1OPRD1OPRK1OPRL1TRPV6 | |
| Hydrochloric Acid SCHEMBL7971161 | 0.99 | OPRM1 (0.40) | OPRM1OPRD1OPRK1OPRL1TRPV6 | |
| SCHEMBL7967371 | 0.79 | CCRL2 (0.43) | OPRM1OPRD1OPRK1OPRL1CCRL2 | |
| Hydrochloric Acid SCHEMBL7971160 | 0.78 | CCRL2 (0.43) | OPRM1OPRD1OPRK1OPRL1CCRL2 | |
| SCHEMBL7963807 | 0.77 | KDM1A (0.45) | OPRM1OPRD1OPRK1OPRL1TRPV6 | |
| SCHEMBL7963809 | 0.77 | KDM1A (0.45) | OPRM1OPRD1OPRK1OPRL1TRPV6 | |
| SCHEMBL7963808 | 0.77 | KDM1A (0.45) | OPRM1OPRD1OPRK1OPRL1TRPV6 | |
| SCHEMBL7966073 | 0.77 | TRPV6 (0.41) | OPRM1OPRD1OPRK1OPRL1TRPV6 | |
| SCHEMBL29448519 | 0.76 | — | — | |
| SCHEMBL659325 | 0.76 | KDM4E (0.48) | OPRM1OPRD1OPRK1OPRL1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358959-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-03-19 | — | — | US | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| WO-2000043374-A1 | POLYAZANAPHTHALENONE DERIVATIVES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-07-27 | — | — | WO | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |