Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | TACR3 | P29371 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705693 | 0.83 | NOS3 (0.42) | POLBNOS3NOS2MAPK10MAOA | |
| SCHEMBL7702043 | 0.76 | NOS3 (0.44) | NOS3NOS2MAPK10MAOAKDM4E | |
| SCHEMBL7702344 | 0.73 | MAOA (0.47) | NOS3NOS2MAPK10MAOACA1 | |
| SCHEMBL7697815 | 0.73 | NOS3 (0.41) | NOS3NOS2MAPK10MAOAKDM4E | |
| SCHEMBL7698312 | 0.72 | NOS3 (0.43) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL13805616 | 0.70 | NOS3 (0.49) | POLBNOS3NOS2MAPK10MAOA | |
| SCHEMBL30965936 | 0.70 | CA1 (0.52) | NOS3NOS2MAPK10MAOAKDM4E | |
| SCHEMBL21063722 | 0.70 | CA1 (0.52) | NOS3NOS2MAPK10MAOAKDM4E | |
| SCHEMBL7704878 | 0.69 | CNR2 (0.47) | — | |
| SCHEMBL12324101 | 0.69 | POLB (0.45) | TRPV1POLBDGAT1ALOX5APHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |