Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704047 | 0.86 | CNR2 (0.65) | CNR2TDO2BRD4CREBBP | |
| SCHEMBL7702043 | 0.77 | NOS3 (0.44) | — | |
| SCHEMBL10094621 | 0.76 | CYP1A2 (0.57) | CNR2FYNTNKSHTR3ACYP1A2 | |
| SCHEMBL7705693 | 0.76 | NOS3 (0.42) | TDO2 | |
| SCHEMBL3241755 | 0.75 | CNR2 (0.56) | CNR2FYNTNKSHTR3ATDO2 | |
| SCHEMBL7699631 | 0.74 | CHKA (0.53) | — | |
| SCHEMBL7702344 | 0.74 | MAOA (0.47) | — | |
| SCHEMBL7697815 | 0.74 | NOS3 (0.41) | — | |
| SCHEMBL10094346 | 0.73 | FYN (0.48) | CNR2FYNTNKSHTR3ATDO2 | |
| SCHEMBL13805616 | 0.70 | NOS3 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1098260-C | 2,4-diaminopyrimidine derivatives | BASLIR PHARMACEUTICALS AG (CH) | 2003-01-08 | — | — | CN | disclosed |
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| CN-1218465-A | 2,4-diaminopyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 1999-06-02 | — | — | CN | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |