Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143172 | 0.92 | GAA (0.38) | GAADHODHKMT2AMEN1HPGD | |
| SCHEMBL7704530 | 0.81 | DHODH (0.37) | DHODHKMT2AMEN1POLBRAB9A | |
| SCHEMBL7704536 | 0.79 | DHODH (0.36) | DHODHKMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL5868988 | 0.78 | KCNQ4 (0.37) | GAAKMT2AMEN1HPGDBLM | |
| SCHEMBL7143926 | 0.74 | DHODH (0.34) | DHODH | |
| SCHEMBL7145960 | 0.73 | EGLN2 (0.36) | DHODHKMT2AMEN1 | |
| SCHEMBL7141050 | 0.72 | CYP17A1 (0.35) | DHODHKMT2AMEN1SMN1; SMN2RAB9A | |
| SCHEMBL7703510 | 0.71 | VCP (0.41) | — | |
| SCHEMBL7704182 | 0.71 | CYP3A4 (0.35) | KMT2AMEN1SMN1; SMN2RAB9AMAPK10 | |
| SCHEMBL7704777 | 0.70 | ALDH1A1 (0.39) | LMNASMN1; SMN2RAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |