Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141050 | 0.92 | CYP17A1 (0.35) | DHODHPARP14RAB9AALDH1A1NPC1 | |
| SCHEMBL7704530 | 0.86 | DHODH (0.37) | DHODHRAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL7140010 | 0.85 | MEN1 (0.36) | DHODHPARP14ALDH1A1KMT2AMEN1 | |
| SCHEMBL7703510 | 0.80 | VCP (0.41) | — | |
| SCHEMBL7145193 | 0.80 | CYP17A1 (0.37) | — | |
| SCHEMBL7704777 | 0.79 | ALDH1A1 (0.39) | RAB9AALDH1A1NPC1SMN1; SMN2MAPT | |
| SCHEMBL7702829 | 0.79 | GAA (0.37) | DHODHRAB9ANPC1SMN1; SMN2KMT2A | |
| SCHEMBL5868818 | 0.79 | CYP17A1 (0.41) | PARP14MAPT | |
| SCHEMBL7704182 | 0.78 | CYP3A4 (0.35) | RAB9AALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7145960 | 0.78 | EGLN2 (0.36) | DHODHALDH1A1KMT2AMEN1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |