Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 2/20 | 0.56 |
| ▸ | RARB | P10826 | 2/20 | 0.56 |
| ▸ | RARG | P13631 | 2/20 | 0.56 |
| ▸ | RXRA | P19793 | 9/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221699 | 0.88 | RARA (0.56) | RARARARBRARGRXRAPGR | |
| SCHEMBL7710016 | 0.84 | RARA (0.57) | RARARARBRARGRXRAPGR | |
| SCHEMBL9144609 | 0.80 | CASP2 (0.42) | RARARARBRARGRXRAPGR | |
| SCHEMBL8603410 | 0.79 | RARB (0.65) | RARARARBRARGRXRABACE1 | |
| SCHEMBL9091776 | 0.78 | RARA (0.51) | RARARARBRARGRXRA | |
| SCHEMBL3496914 | 0.78 | RXRA (0.47) | RARARARBRARGRXRAPGR | |
| SCHEMBL7703951 | 0.78 | RARA (0.46) | RARARARBRARGRXRAPGR | |
| SCHEMBL15577372 | 0.77 | PGR (0.41) | RARARARBRARGPGRBACE1 | |
| SCHEMBL31559289 | 0.77 | PGR (0.41) | RARARARBRARGPGRBACE1 | |
| SCHEMBL7709681 | 0.75 | RARA (0.46) | RARARARBRARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | claimed |
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0825986-A1 | QUINOLYL-ETHYNYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | Allergan (US) | 1998-03-04 | — | — | EP | disclosed |
| US-5616712-A | SKIN DISORDERS; ANTICARCINOGENIC AND -INFLAMMATORY AGENTS; AUTOIMMUNE DISEASES; | ALLERGAN (US) | 1997-04-01 | — | — | US | disclosed |
| WO-1996036609-A1 | QUINOLYL-ETHYNYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | ALLERGAN (US) | 1996-11-21 | — | — | WO | disclosed |