Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 2/20 | 0.57 |
| ▸ | RARB | P10826 | 2/20 | 0.57 |
| ▸ | RARG | P13631 | 2/20 | 0.57 |
| ▸ | RXRA | P19793 | 9/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703988 | 0.88 | RARA (0.57) | RARARARBRARGRXRAHSD17B10 | |
| SCHEMBL7703905 | 0.84 | RARA (0.56) | RARARARBRARGRXRAPGR | |
| SCHEMBL8603410 | 0.80 | RARB (0.65) | RARARARBRARGRXRA | |
| SCHEMBL9091776 | 0.80 | RARA (0.51) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL14533938 | 0.80 | OPRM1 (0.42) | RARARARBRARGRXRAHSD17B10 | |
| SCHEMBL7703951 | 0.79 | RARA (0.46) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL3496914 | 0.77 | RXRA (0.47) | RARARARBRARGRXRAPGR | |
| SCHEMBL7709681 | 0.77 | RARA (0.46) | RARARARBRARGRXRAHSD17B10 | |
| SCHEMBL8632000 | 0.76 | RARB (0.67) | RARARARBRARGRXRA | |
| SCHEMBL7709931 | 0.75 | RARA (0.56) | RARARARBRARGRXRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |