Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | TACR2 | P21452 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 5/20 | 0.45 |
| ▸ | MMP9 | P14780 | 4/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695923 | 0.90 | ITGB1 (0.52) | KCNA5CASP1CAPN1BCL2L1TACR2 | |
| SCHEMBL7695358 | 0.87 | CHRNB2 (0.47) | KCNA5CAPN1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7428250 | 0.84 | KCNA5 (0.44) | KCNA5CASP1CAPN1BCL2L1MMP2 | |
| SCHEMBL7701336 | 0.83 | CASP1 (0.49) | KCNA5CASP1MMP2MMP9ADAMTS4 | |
| SCHEMBL7689922 | 0.82 | CAPN1 (0.57) | KCNA5CASP1CAPN1MMP2MMP9 | |
| SCHEMBL7698402 | 0.80 | CHRNB2 (0.52) | KCNA5CAPN1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7689953 | 0.80 | CHRNB2 (0.52) | CAPN1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7705654 | 0.79 | CAPN1 (0.46) | KCNA5CASP1CAPN1MMP9CA2 | |
| SCHEMBL7693964 | 0.78 | CAPN1 (0.50) | KCNA5CASP1CAPN1 | |
| SCHEMBL7701518 | 0.78 | CA2 (0.44) | KCNA5CASP1CAPN1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |