SCHEMBL7701336

SCHEMBL7701336

O=C(N[C@@H](Cc1ccccc1)C(=O)CNS(=O)(=O)c1ccccc1)c1ccccc1Oc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.49
MMP2 P08253 5/20 0.44
ADAMTS4 O75173 2/20 0.44
MMP1 P03956 1/20 0.44
MMP13 P45452 1/20 0.44
MMP14 P50281 1/20 0.44
MEP1B Q16820 1/20 0.44
ADAMTS5 Q9UNA0 1/20 0.44
KCNA5 P22460 2/20 0.43
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
ATM Q13315 1/20 0.42
MEN1 O00255 1/20 0.41
RECQL P46063 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7701622 0.88 L3MBTL1 (0.44) L3MBTL1ALDH1A1GAAHPGDHTT
SCHEMBL7675029 0.86 L3MBTL1 (0.44) CASP1MMP2ADAMTS4MMP1MMP13
SCHEMBL7704469 0.83 KCNA5 (0.52) CASP1MMP2ADAMTS4MMP1KCNA5
SCHEMBL7694147 0.82 ACE (0.46) MMP1L3MBTL1ALDH1A1GAAHPGD
SCHEMBL7694696 0.82 KDM4E (0.47) L3MBTL1ALDH1A1GAAHPGDHTT
SCHEMBL7689922 0.78 CAPN1 (0.57) CASP1MMP2KCNA5MMP9
SCHEMBL7701518 0.77 CA2 (0.44) CASP1KCNA5CA2
SCHEMBL7705654 0.76 CAPN1 (0.46) CASP1KCNA5ALDH1A1CA2MMP9
SCHEMBL7701291 0.76 GFER (0.41) CASP1MMP2ADAMTS4MMP1MMP13
SCHEMBL7698802 0.75 CAPN1 (0.67) CASP1KCNA5CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6436925-B1 BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES ABBOTT LABORATORIES 2002-08-20 US disclosed