Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 12/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024149 | 0.87 | SIGMAR1 (0.43) | SIGMAR1GRM2MEN1KMT2AF10 | |
| SCHEMBL7704866 | 0.85 | GRM2 (0.41) | SIGMAR1GRM2F10 | |
| SCHEMBL7520241 | 0.84 | MAOA (0.48) | F10 | |
| SCHEMBL8024076 | 0.78 | GRM2 (0.43) | GRM2F10 | |
| SCHEMBL8013254 | 0.76 | GRM2 (0.42) | SIGMAR1GRM2F10 | |
| SCHEMBL7153924 | 0.76 | GRM2 (0.42) | SIGMAR1GRM2F10 | |
| SCHEMBL7710710 | 0.76 | MAOA (0.48) | — | |
| SCHEMBL8646554 | 0.75 | MAOA (0.45) | F10 | |
| SCHEMBL6400506 | 0.74 | MAOA (0.49) | F10 | |
| SCHEMBL6400513 | 0.74 | MAOA (0.49) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365751-B1 | ACTIVE AGAINST GRAM-POSITIVE BACTERIA, IN PARTICULAR, AGAINST STRAINS RESISTANT TO VANCOMYCIN, AMINOGLYCOSIDES AND PENCILLINS AND DERIVATIVES; NONTOXIC | ZENECA LTD. (GB) | 2002-04-02 | — | — | US | disclosed |