Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10925979 | 0.78 | ADORA3 (0.54) | ALDH1A1KDM4EPOLBKMT2AMAPT | |
| SCHEMBL9054221 | 0.77 | L3MBTL1 (0.64) | GAASMN1; SMN2ALDH1A1POLBKMT2A | |
| SCHEMBL9819864 | 0.76 | SIGMAR1 (0.69) | GAASMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL5242857 | 0.75 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL6044228 | 0.75 | ALDH1A1 (0.49) | GAAALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL28312981 | 0.75 | HRH1 (0.52) | ALDH1A1KDM4EPOLB | |
| SCHEMBL7224481 | 0.74 | GAA (1.00) | GAASMN1; SMN2ALDH1A1KDM4EKMT2A | |
| SCHEMBL27678708 | 0.74 | HRH3 (1.00) | GAAALDH1A1KDM4EHRH3MAPT | |
| SCHEMBL9513162 | 0.74 | HRH2 (0.60) | ALDH1A1KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL10902416 | 0.73 | HRH2 (0.67) | SMN1; SMN2ALDH1A1KMT2AMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242399-A1 | $g(a)-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS | UCB S.A. (BE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046167-A1 | α-ARYLETHYLPIPERAZINE DERIVATIVES AS NEUROKININ ANTAGONISTS | UCB, S.A. (BE) | 2001-06-28 | — | — | WO | disclosed |