Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6257638 | 0.89 | CYP2D6 (0.44) | CYP2D6LMNAMAPK1HTTABCB1 | |
| SCHEMBL7713731 | 0.89 | ABCB1 (0.42) | CYP2D6LMNAMAPK1HTTABCB1 | |
| SCHEMBL7708649 | 0.87 | SLC6A3 (0.45) | LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7708678 | 0.85 | MAPT (0.43) | CYP2D6LMNAMAPK1MEN1KMT2A | |
| SCHEMBL7711594 | 0.81 | LMNA (0.47) | CYP2D6LMNAMAPK1HTTMEN1 | |
| SCHEMBL6260919 | 0.78 | HTR1A (0.53) | MEN1KMT2A | |
| SCHEMBL7708651 | 0.75 | CACNA1G (0.43) | LMNAABCB1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7711797 | 0.75 | MEN1 (0.48) | CYP2D6LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7711567 | 0.74 | CHRNA7 (0.44) | LMNAMAPK1ABCB1MEN1KMT2A | |
| SCHEMBL6188797 | 0.74 | CYP2D6 (0.55) | CYP2D6LMNAMAPK1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259493-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2002-11-27 | — | — | EP | claimed |
| WO-2001062744-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2001-08-30 | — | — | WO | claimed |
| EP-1259493-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001062744-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2001-08-30 | — | — | WO | disclosed |