Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705260 | 0.75 | PRMT5 (0.44) | PRMT5WDR77MEN1KMT2ALMNA | |
| SCHEMBL7077882 | 0.75 | CYP3A4 (0.61) | PRMT5WDR77MEN1KMT2ALMNA | |
| SCHEMBL7708649 | 0.73 | SLC6A3 (0.45) | MEN1KMT2ALMNASMN1; SMN2DRD2 | |
| SCHEMBL7705235 | 0.71 | CYP2D6 (0.54) | MEN1KMT2ALMNASMN1; SMN2CYP2D6 | |
| SCHEMBL7711594 | 0.70 | LMNA (0.47) | MEN1KMT2ALMNASMN1; SMN2NPY1R | |
| SCHEMBL7713731 | 0.69 | ABCB1 (0.42) | MEN1KMT2ALMNASMN1; SMN2CYP2D6 | |
| SCHEMBL7708678 | 0.69 | MAPT (0.43) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL15943831 | 0.69 | PRMT5 (1.00) | PRMT5WDR77CYP2D6CYP2C19 | |
| SCHEMBL7708651 | 0.69 | CACNA1G (0.43) | MEN1KMT2ALMNASMN1; SMN2TSHR | |
| SCHEMBL7711797 | 0.69 | MEN1 (0.48) | MEN1KMT2ALMNASMN1; SMN2NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259493-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2002-11-27 | — | — | EP | claimed |
| WO-2001062744-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2001-08-30 | — | — | WO | claimed |
| EP-1259493-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001062744-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2001-08-30 | — | — | WO | disclosed |