Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711760 | 0.94 | MEN1 (0.39) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7705247 | 0.81 | MEN1 (0.39) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7713731 | 0.78 | ABCB1 (0.42) | MEN1KMT2ALMNASMN1; SMN2MAPK1 | |
| SCHEMBL7708651 | 0.77 | CACNA1G (0.43) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7708649 | 0.75 | SLC6A3 (0.45) | MEN1KMT2ALMNASMN1; SMN2SLC6A4 | |
| SCHEMBL6281680 | 0.75 | CYP3A4 (0.56) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL7711594 | 0.74 | LMNA (0.47) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7711567 | 0.74 | CHRNA7 (0.44) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7711797 | 0.73 | MEN1 (0.48) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7705235 | 0.71 | CYP2D6 (0.54) | MEN1KMT2ALMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259493-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001062744-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2001-08-30 | — | — | WO | disclosed |