Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701012 | 0.81 | NOS3 (0.49) | NOS3NOS2MAOALMNAMAPT | |
| SCHEMBL7701128 | 0.79 | CYP1A2 (0.46) | MAPK10MAPK14MAPK9LMNAMAPT | |
| SCHEMBL7704052 | 0.79 | GRIN2D (0.45) | NOS3NOS2MAPK10MAOALMNA | |
| SCHEMBL7698058 | 0.79 | NOS3 (0.44) | NOS3NOS2MAPK10MAPK14MAPK9 | |
| SCHEMBL7705872 | 0.78 | MAOA (0.52) | NOS3NOS2MAPK10MAPK14MAPK9 | |
| SCHEMBL28341424 | 0.77 | MAPK10 (0.64) | NOS3NOS2MAPK10MAPK14MAPK9 | |
| SCHEMBL7705613 | 0.77 | NOS3 (0.45) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL5673245 | 0.77 | CCR1 (0.46) | MAPK14MAPTCCR1CCR5CCR8 | |
| SCHEMBL28190730 | 0.77 | NOS3 (0.55) | NOS3NOS2MAPK10MAPK14MAPK9 | |
| SCHEMBL30109433 | 0.76 | NOS3 (0.44) | NOS3NOS2MAPK10MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1098260-C | 2,4-diaminopyrimidine derivatives | BASLIR PHARMACEUTICALS AG (CH) | 2003-01-08 | — | — | CN | disclosed |
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| CN-1218465-A | 2,4-diaminopyrimidine derivatives | HOFFMANN LA ROCHE (CH) | 1999-06-02 | — | — | CN | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |