Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 7/20 | 0.40 |
| ▸ | CCND1 | P24385 | 7/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703248 | 0.86 | ADORA2A (0.46) | GBA1DHFRKDM4E | |
| SCHEMBL7709059 | 0.75 | SMN1; SMN2 (0.45) | KDM4EMEN1KMT2AGAA | |
| SCHEMBL7705992 | 0.74 | HPGD (0.45) | KDM4EMEN1KMT2AGAA | |
| SCHEMBL7436334 | 0.72 | HTT (0.50) | KDM4EMEN1KMT2AGAA | |
| SCHEMBL21588453 | 0.69 | KDM4E (0.51) | DHFRKDM4ETRPV1SIGMAR1MEN1 | |
| SCHEMBL21588421 | 0.69 | DHFR (0.53) | GBA1DHFRKDM4ETRPV1FAAH | |
| SCHEMBL6867881 | 0.68 | ADORA2A (0.63) | CDK4CCND1 | |
| SCHEMBL6262143 | 0.68 | KDM4E (0.49) | GBA1DHFRKDM4ETRPV1SIGMAR1 | |
| SCHEMBL21588327 | 0.66 | KDM4E (0.56) | KDM4ETRPV1SIGMAR1MEN1KMT2A | |
| SCHEMBL7423524 | 0.66 | ALDH1A1 (0.53) | KDM4EMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |