Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 2/20 | 0.62 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.56 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.53 |
| ▸ | DHFR | P00374 | 1/20 | 0.53 |
| ▸ | HNF4A | P41235 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13805528 | 0.90 | SIRT6 (0.65) | TOP1SIRT6PTPN1DEGS1KMT2A | |
| SCHEMBL3654104 | 0.89 | SIRT6 (0.59) | TOP1SIRT6PTPN1KMT2AMEN1 | |
| SCHEMBL25452049 | 0.87 | PTPN1 (0.59) | TOP1PTPN1DEGS1KMT2AMEN1 | |
| SCHEMBL10758235 | 0.86 | SIRT6 (0.64) | SIRT6PTPN1DEGS1KMT2AMEN1 | |
| SCHEMBL3662655 | 0.81 | NPC1 (0.65) | SIRT6DEGS1KMT2AMEN1ACMSD | |
| SCHEMBL1129948 | 0.79 | KMT2A (0.77) | SIRT6PTPN1KMT2AMEN1PKM | |
| SCHEMBL13805546 | 0.79 | SIRT6 (0.53) | SIRT6PTPN1KMT2AMEN1MCL1 | |
| SCHEMBL10759208 | 0.78 | MITF (0.64) | SIRT6PTPN1KMT2AMEN1PKM | |
| SCHEMBL3757836 | 0.78 | KMT2A (0.69) | TOP1KMT2AMEN1PKMPOLB | |
| SCHEMBL11166112 | 0.78 | TOP1 (0.86) | TOP1PTPN1KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417178-B1 | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits | UNIVERSITY OF PITTSBURGH | 2002-07-09 | — | — | US | disclosed |