Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 6/20 | 0.74 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709292 | 0.85 | HCRTR2 (1.00) | HCRTR2HCRTR1LMNATSPOTP53 | |
| SCHEMBL7707649 | 0.80 | HCRTR2 (0.82) | HCRTR2HCRTR1AOC3LMNAPOLB | |
| SCHEMBL2594714 | 0.78 | HCRTR2 (0.64) | HCRTR2HCRTR1LMNAPOLB | |
| SCHEMBL7707208 | 0.76 | HCRTR2 (0.81) | HCRTR2HCRTR1AOC3LMNAPOLB | |
| SCHEMBL7706361 | 0.76 | HCRTR2 (0.62) | HCRTR2HCRTR1LMNA | |
| SCHEMBL7709056 | 0.75 | HCRTR2 (0.82) | HCRTR2HCRTR1AOC3LMNATSPO | |
| SCHEMBL7707551 | 0.73 | HCRTR2 (0.71) | HCRTR2HCRTR1AOC3LMNATSPO | |
| SCHEMBL7702437 | 0.71 | HCRTR1 (0.81) | HCRTR2HCRTR1LMNAPOLBTP53 | |
| SCHEMBL7712431 | 0.71 | HCRTR2 (0.66) | HCRTR2HCRTR1AOC3LMNAPOLB | |
| SCHEMBL7707423 | 0.69 | HCRTR2 (1.00) | HCRTR2HCRTR1POLBTSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |