Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556812 | 0.79 | ROCK2 (0.60) | MAPTROCK2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL7707825 | 0.76 | ROCK2 (0.57) | MAPTROCK2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL8554376 | 0.76 | ROCK2 (0.56) | MAPTROCK2TP53SMN1; SMN2POLB | |
| SCHEMBL18073895 | 0.75 | ROCK2 (0.56) | MAPTROCK2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL7701986 | 0.73 | ROCK2 (0.54) | MAPTROCK2TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL8629096 | 0.73 | MAPT (0.55) | KMT2AMAPTALDH1A1POLBKDM4E | |
| SCHEMBL7707705 | 0.73 | SMN1; SMN2 (0.42) | KMT2AMAPTROCK2IMPDH2TP53 | |
| SCHEMBL8553623 | 0.72 | ALDH1A1 (0.44) | KMT2AMAPTROCK2IMPDH2TP53 | |
| SCHEMBL8557970 | 0.71 | MAPT (0.40) | KMT2AMAPTROCK2IMPDH2TP53 | |
| SCHEMBL8624225 | 0.71 | ROCK2 (0.41) | KMT2AMAPTROCK2IMPDH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |