Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8624225 | 0.93 | ROCK2 (0.41) | SMN1; SMN2KMT2AATMMAPTPOLB | |
| SCHEMBL8629096 | 0.88 | MAPT (0.55) | MEN1KMT2AMAPTPOLBKDM4E | |
| SCHEMBL18073895 | 0.86 | ROCK2 (0.56) | SMN1; SMN2L3MBTL1MAPTPOLBROCK2 | |
| SCHEMBL7422800 | 0.83 | KMT2A (0.58) | SMN1; SMN2MEN1KMT2AATML3MBTL1 | |
| SCHEMBL8553623 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2AMAPTPOLB | |
| SCHEMBL8557970 | 0.82 | MAPT (0.40) | SMN1; SMN2MEN1KMT2AMAPTPOLB | |
| SCHEMBL7710536 | 0.81 | HDAC3 (0.46) | SMN1; SMN2MEN1KMT2AMAPTROCK2 | |
| SCHEMBL8556645 | 0.80 | PARP1 (0.52) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL8554262 | 0.78 | ALDH1A1 (0.54) | SMN1; SMN2MEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL8555826 | 0.78 | KMT2A (0.44) | SMN1; SMN2MEN1KMT2AATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |