Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245709 | 0.91 | AOC3 (0.54) | AOC3DAODHFRPLA2G7 | |
| SCHEMBL11542383 | 0.83 | AOC3 (0.60) | AOC3PLA2G7 | |
| SCHEMBL7712467 | 0.82 | PLA2G7 (0.50) | DAOPLA2G7 | |
| Trifluoroacetic Acid SCHEMBL4245210 | 0.81 | AOC3 (0.44) | AOC3DAODHFR | |
| SCHEMBL10986003 | 0.78 | LMNA (0.58) | PLA2G7 | |
| SCHEMBL7716580 | 0.76 | DAO (0.50) | AOC3DAOPLA2G7 | |
| SCHEMBL10733027 | 0.75 | LMNA (0.58) | PLA2G7 | |
| SCHEMBL23812457 | 0.74 | AOC3 (0.67) | AOC3DAO | |
| SCHEMBL4211345 | 0.74 | TK1 (0.36) | AOC3 | |
| SCHEMBL7716692 | 0.72 | QTRT1 (0.52) | DAOPLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |