Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 3/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716578 | 0.87 | PLA2G7 (0.48) | QTRT1PLA2G7TYMSXDH | |
| SCHEMBL7716580 | 0.81 | DAO (0.50) | DAOPLA2G7TYMSTAAR1XDH | |
| SCHEMBL8239236 | 0.80 | BACE1 (0.53) | DAODHODHABCB1 | |
| SCHEMBL7712501 | 0.74 | XDH (0.45) | TYMSXDH | |
| SCHEMBL7708037 | 0.72 | AOC3 (0.51) | DAOPLA2G7 | |
| SCHEMBL13039021 | 0.71 | NOS1 (0.42) | TYMS | |
| SCHEMBL5202767 | 0.71 | PDE3B (0.47) | DAOPLA2G7XDH | |
| SCHEMBL4211345 | 0.71 | TK1 (0.36) | TYMS | |
| SCHEMBL834551 | 0.69 | TAAR1 (0.73) | TAAR1 | |
| SCHEMBL10736648 | 0.69 | PLA2G7 (0.49) | DAOPLA2G7FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440965-B1 | Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system | KRENITSKY PHARMACEUTICALS, INC. | 2002-08-27 | — | — | US | disclosed |