Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 5/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYBB | P04839 | 1/20 | 0.33 |
| ▸ | NOX3 | Q9HBY0 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708360 | 0.89 | ADAMTS5 (0.40) | NOS3NOS1NOS2LMNAMAPT | |
| SCHEMBL7713419 | 0.81 | NOS3 (0.43) | NOS3NOS1NOS2MAPTPTPN5 | |
| SCHEMBL6999115 | 0.69 | LMNA (0.47) | LMNAMAPTPTPN5TP53SMN1; SMN2 | |
| SCHEMBL6993134 | 0.69 | LMNA (0.60) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL8523594 | 0.68 | LMNA (0.50) | LMNAMAPTTP53SMN1; SMN2L3MBTL1 | |
| SCHEMBL7708028 | 0.64 | NOS3 (0.43) | NOS3NOS1NOS2CTSDEPHX2 | |
| SCHEMBL7000029 | 0.62 | LMNA (0.45) | LMNAMAPTPTPN5TP53SMN1; SMN2 | |
| SCHEMBL7004061 | 0.62 | LMNA (0.58) | LMNAMAPTTP53SMN1; SMN2HTT | |
| SCHEMBL22620409 | 0.62 | CHRNB2 (0.37) | NOS3NOS1NOS2CTSD | |
| SCHEMBL19730975 | 0.61 | NOX1 (0.41) | MAPTPTPN5CYBBNOX3NOX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365736-B1 | TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-04-02 | — | — | US | disclosed |