SCHEMBL7708671

SCHEMBL7708671

[N]C(=O)c1cc(F)c(F)c(F)c1C(=O)F

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
CA4 P22748 2/20 0.38
CES2 O00748 4/20 0.36
CES1 P23141 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9693376 0.76 CA1 (0.50) CA1CA2CA4CES2CES1
Fluoride SCHEMBL28471026 0.73 CES2 (0.46) CA1CA2CA4CES2CES1
SCHEMBL4851418 0.73 CES2 (0.46) CA1CA2CA4CES2CES1
SCHEMBL9693672 0.71 CA1 (0.61) CA1CA2CA4CES2CES1
SCHEMBL31041213 0.68 KEAP1 (0.44) CA1CA2CA4CES2CES1
SCHEMBL5336692 0.68 KEAP1 (0.44) CA1CA2CA4CES2CES1
SCHEMBL8084936 0.67 CA1 (0.40) CA1CA2CA4CES2CES1
SCHEMBL8081987 0.67 CA1 (0.40) CA1CA2CA4CES2CES1
SCHEMBL8072641 0.67 ALDH1A1 (0.43) CA1CA2CA4CES2CES1
SCHEMBL1900629 0.67 CES2 (0.39) CA1CA2CA4CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355615-B1 CYCLIC POLYAMIDEESTER COPOLYMERS BAYER AKTIENGESELLSCHAFT (DE) 2002-03-12 US claimed
EP-0986549-A1 DESOXYCYCLODEPSIPEPTIDES AND THEIR USE FOR COMBATTING ENDOPARASITES Bayer Aktiengesellschaft (DE) 2000-03-22 EP claimed
WO-1998055469-A1 DESOXYCYCLODEPSIPEPTIDES AND THEIR USE FOR COMBATTING ENDOPARASITES BAYER AKTIENGESELLSCHAFT (DE) 1998-12-10 WO claimed
US-6355615-B1 CYCLIC POLYAMIDEESTER COPOLYMERS BAYER AKTIENGESELLSCHAFT (DE) 2002-03-12 US disclosed
EP-0986549-A1 DESOXYCYCLODEPSIPEPTIDES AND THEIR USE FOR COMBATTING ENDOPARASITES Bayer Aktiengesellschaft (DE) 2000-03-22 EP disclosed
WO-1998055469-A1 DESOXYCYCLODEPSIPEPTIDES AND THEIR USE FOR COMBATTING ENDOPARASITES BAYER AKTIENGESELLSCHAFT (DE) 1998-12-10 WO disclosed