Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426342 | 0.86 | TSHR (0.44) | TSHRSMN1; SMN2RAB9APOLBGAA | |
| SCHEMBL10474823 | 0.85 | NPC1 (0.45) | TSHRSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL7543301 | 0.82 | GABRG2 (0.43) | SMN1; SMN2ALDH1A1LMNAGABRA1GABRG2 | |
| SCHEMBL7714538 | 0.78 | KMT2A (0.48) | TSHRSMN1; SMN2TP53GAAALDH1A1 | |
| SCHEMBL7543466 | 0.78 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL29433567 | 0.76 | TSHR (0.47) | TSHRSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL7712683 | 0.76 | TSHR (0.47) | TSHRSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL10472815 | 0.75 | NPC1 (0.47) | TSHRSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL7714827 | 0.73 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL7714706 | 0.72 | TSHR (0.44) | TSHRGAAALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369110-B1 | PROPHYLACTIC AGENT FOR DISEASES CAUSED BY THE ACCELERATION OF THE SODIUM/PROTON EXCHANGE TRANSPORT SYSTEM | SUMITOMO PHARMACEUTICALS COMPANY (JP) | 2002-04-09 | — | — | US | disclosed |
| EP-1083166-A1 | NOVEL SUBSTITUTED GUANIDINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-03-14 | — | — | EP | disclosed |