Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.33 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721427 | 1.00 | MTNR1B (0.36) | MTNR1BSCN9ANPY1RRAMP1CALCRL | |
| SCHEMBL7718518 | 1.00 | MTNR1B (0.36) | MTNR1BSCN9ANPY1RRAMP1CALCRL | |
| SCHEMBL7719303 | 0.96 | SCN9A (0.38) | MTNR1BSCN9ANPY1RDRD2 | |
| SCHEMBL7717555 | 0.96 | SCN9A (0.38) | MTNR1BSCN9ANPY1RDRD2 | |
| SCHEMBL7713113 | 0.86 | KDM4D (0.33) | SCN9A | |
| SCHEMBL7718967 | 0.86 | KDM4D (0.33) | SCN9A | |
| SCHEMBL7718415 | 0.86 | KDM4D (0.33) | SCN9A | |
| SCHEMBL7719034 | 0.79 | MTNR1B (0.35) | MTNR1BSCN9ANPY1RKMT2A | |
| SCHEMBL7715083 | 0.78 | KMT2A (0.34) | NPY1RDRD2KMT2AL3MBTL1 | |
| SCHEMBL7717533 | 0.78 | MTNR1B (0.35) | MTNR1BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1214326-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001018006-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2001-03-15 | — | — | WO | disclosed |