SCHEMBL7709582

SCHEMBL7709582

CC(=O)CC(=O)OCCC(=O)NOc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.33
MEN1 O00255 5/20 0.33
KMT2A Q03164 5/20 0.33
ALDH1A1 P00352 3/20 0.32
RAB9A P51151 1/20 0.32
FFAR1 O14842 1/20 0.32
EGLN1 Q9GZT9 1/20 0.32
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
MAPK1 P28482 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
POLB P06746 1/20 0.31
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7125661 0.86 L3MBTL1 (0.38) NPC1MEN1KMT2AALDH1A1RAB9A
SCHEMBL7117619 0.84 PLK1 (0.38) EGLN1GAATDP1POLB
SCHEMBL7709554 0.76 MAPT (0.34) NPC1MEN1KMT2AALDH1A1RAB9A
SCHEMBL13897459 0.74 KMT2A (0.50) NPC1MEN1KMT2AALDH1A1RAB9A
SCHEMBL30887148 0.73 HPGD (0.42) NPC1GAAMAPTTDP1LMNA
SCHEMBL6551878 0.73 PDIA6 (0.37) NPC1GAATDP1
SCHEMBL25373978 0.73 PPARG (0.36) NPC1MEN1KMT2AALDH1A1RAB9A
SCHEMBL28965238 0.72 LMNA (0.47) NPC1MEN1KMT2AALDH1A1GAA
SCHEMBL7703825 0.72
SCHEMBL30887231 0.72 HTT (0.43) NPC1MEN1KMT2AALDH1A1FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6355708-B2 USEFUL IN STABILIZING POLYMERS AND OTHER MATERIALS FROM DEGRADATION BY ENVIRONMENTAL FORCES SUCH AS ACTINIC RADIATION (ULTRAVIOLET LIGHT), OXIDATION, MOISTURE, ATMOSPHERIC POLLUTANTS CIBA SPECIALTY CHEMICALS CORPORATION 2002-03-12 US disclosed
US-20010031866-A1 Novel trisaryl-1,3,5-triazine ultraviolet light absorbers GUPTA RAM BABOO (US) 2001-10-18 US disclosed
US-6242597-B1 STABILIZERS WITH A BONDABLE GROUP HAVING AN ACTIVE (ACIDIC) HYDROGEN; MIGRATION BETWEEN POLYMER LAYERS IS REDUCED CIBA SPECIALTY CHEMICALS CORPORATION 2001-06-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010031866-A1 Novel trisaryl-1,3,5-triazine ultraviolet light absorbers ERCC5, XRCC5, ERCC1 NPC1 2328/4885MEN1 2954/4885KMT2A 2545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.