Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | LAP3 | P28838 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 11/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590490 | 0.90 | LMNA (0.52) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL718199 | 0.90 | LMNA (0.52) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL5221398 | 0.90 | LMNA (0.52) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL6897546 | 0.90 | MMP1 (0.46) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL27403149 | 0.90 | MMP1 (0.46) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL7302285 | 0.90 | LTA4H (0.56) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL12615481 | 0.88 | MAPT (0.48) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL5115273 | 0.88 | MAPT (0.48) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL716533 | 0.88 | MAPT (0.48) | MAPTLMNALTA4HLAP3P2RX7 | |
| SCHEMBL8813869 | 0.86 | P2RX7 (0.47) | MAPTLMNALTA4HLAP3P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362165-B1 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties | PHARMACOR INC. (CA) | 2002-03-26 | — | — | US | disclosed |