Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 2/20 | 0.56 |
| ▸ | RARB | P10826 | 2/20 | 0.56 |
| ▸ | RARG | P13631 | 2/20 | 0.56 |
| ▸ | RXRA | P19793 | 9/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | FSHR | P23945 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703988 | 0.84 | RARA (0.57) | RARARARBRARGRXRAPGR | |
| SCHEMBL6221699 | 0.82 | RARA (0.56) | RARARARBRARGRXRAPGR | |
| SCHEMBL17675353 | 0.82 | RARA (0.56) | RARARARBRARGRXRAPGR | |
| SCHEMBL9593284 | 0.80 | CYP19A1 (0.46) | RARARARBRARGRXRACYP19A1 | |
| SCHEMBL9092549 | 0.80 | RARA (0.54) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL6222999 | 0.79 | RARA (0.56) | RARARARBRARGRXRAPGR | |
| SCHEMBL9091776 | 0.78 | RARA (0.51) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL7709681 | 0.78 | RARA (0.46) | RARARARBRARGRXRAATAD2 | |
| SCHEMBL5010350 | 0.77 | ALDH1A1 (0.39) | RARARARBRARGPGRCYP19A1 | |
| SCHEMBL8310907 | 0.77 | ATAD2 (0.55) | RXRAPGRCYP19A1ATAD2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |